Go to your local games stores/hobby centers/comic book stores and see what is played frequently and often that you enjoy. DOn't buy into a game system that no one locally plays. Also... make sure that you get along with the locals that play.
When I was in college I played 40k... when I came back home there were very few people that played (they were still into the Magic craze and the newer Star Wars card craze) and those few that did play were older... very grumpy and didn't like outsiders, so I tried getting my friends to play... very few wanted to drop coin on their own stuff, but were willing to use my pieces. HAH! That didn't last long.
So.. make sure there is a player base for the game/s that you want to play and that said player base is accepting of new blood before spending any money on a game.